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Published on: October 24, 2016
Multiple endocrine neoplasia in a dog
M Kiupel1, P B Mueller, J Ramos Vara
1Animal Disease Diagnostic Laboratory, Purdue University, West Lafayette, IN 47907, USA.
Journal of Comparative Pathology
|October 18, 2000
Summary
A dog diagnosed with multiple endocrine neoplasms exhibited insulinoma, adrenocortical adenocarcinomas, and paraganglioma. These findings mirror human multiple endocrine neoplasia syndromes.
Area of Science:
- Veterinary Pathology
- Comparative Pathology
- Endocrinology
Background:
- Multiple endocrine neoplasia (MEN) syndromes are rare inherited disorders in humans characterized by tumors in endocrine glands.
- Understanding these syndromes in animals can provide insights into human disease mechanisms and potential therapeutic targets.
Observation:
- A 12-year-old mixed-breed dog presented with anorexia, vomiting, diarrhea, weight loss, polyuria, polydipsia, regenerative anemia, and hypoglycemia.
- Post-euthanasia examination revealed multiple endocrine neoplasms: an insulinoma, bilateral adrenocortical adenocarcinomas, and an aortic paraganglioma.
Findings:
- Histopathological, immunohistochemical, and ultrastructural analyses confirmed the diagnoses of the endocrine tumors.
- The combination of tumors observed in the dog closely resembles the human MEN syndrome.
Implications:
- This case highlights the occurrence of multiple endocrine neoplasms in dogs, presenting a valuable animal model for studying human MEN.
- Further research into canine endocrine neoplasia can advance comparative oncology and endocrine disease understanding.
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