Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Clinically relevant adverse drug interactions].

M Martin-Facklam1, W E Haefeli

  • 1Abteilung Innere Medizin VI, Universitätsklinikum Heidelberg. meret_martin-facklam@med.uni-heidelberg.de

Therapeutische Umschau. Revue Therapeutique
|October 19, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Assessing the perspective of well-being of older patients with multiple morbidities by using the LAVA tool - a person-centered approach.

BMC geriatrics·2021
Same author

[Epidemiology and prevention of heat-related adverse health effects on elderly people].

Zeitschrift fur Gerontologie und Geriatrie·2019
Same author

Association of generalized anxiety symptoms and panic with health care costs in older age-Results from the ESTHER cohort study.

Journal of affective disorders·2018
Same author

The NTCP-inhibitor Myrcludex B: Effects on Bile Acid Disposition and Tenofovir Pharmacokinetics.

Clinical pharmacology and therapeutics·2017
Same author

A randomized controlled trial to assess the effect of a medication plan containing drug administration recommendations on patients' drug knowledge after 2 months.

Journal of clinical pharmacy and therapeutics·2016
Same author

[Formal prescribing errors are substantially reduced in electronic prescribing and after teaching sessions].

Deutsche medizinische Wochenschrift (1946)·2015
Same journal

[Multimodal Cardiac Imaging: New Developments for Clinical Practice].

Therapeutische Umschau. Revue therapeutique·2026
Same journal

[Coronary angiography: From cardiac catheterization to advanced interventional cardiovascular imaging].

Therapeutische Umschau. Revue therapeutique·2026
Same journal

[Athlete's heart: role of cardiac imaging in the prevention of sudden cardiac death].

Therapeutische Umschau. Revue therapeutique·2026
Same journal

[Multimodal imaging in cardiac amyloidosis and cardiac sarcoidosis].

Therapeutische Umschau. Revue therapeutique·2026
Same journal

[Inflammatory Heart Disease: The Role of Multimodality Cardiac Imaging in Myocarditis and Pericarditis].

Therapeutische Umschau. Revue therapeutique·2026
Same journal

State-of-the-Art Cardiac Imaging

Therapeutische Umschau. Revue therapeutique·2026
See all related articles

Drug interactions can cause adverse effects or treatment failure. Understanding cytochrome P450 and p-glycoprotein activity helps predict and prevent these interactions through dose adjustments or alternative medications.

Area of Science:

  • Pharmacology
  • Drug Metabolism
  • Drug Transport

Background:

  • Drug interactions pose significant risks, including adverse drug effects and therapeutic failure.
  • Key mechanisms involve alterations in cytochrome P450 (CYP) enzyme activity and drug transporter systems like p-glycoprotein.
  • These interactions are a major concern in clinical practice.

Purpose of the Study:

  • To highlight the mechanisms of clinically relevant drug interactions.
  • To emphasize the roles of CYP enzymes and drug transporters in these interactions.
  • To underscore the importance of anticipating and preventing drug interactions.

Main Methods:

  • Review of literature on drug metabolism and transport.
  • Analysis of common drug interaction pathways.

Related Experiment Videos

  • Identification of key enzymes and transporters involved.

    • Main Results:

    • Cytochrome P450 isoenzymes and p-glycoprotein are critical determinants of drug disposition and interaction.
    • Changes in the activity of these systems frequently underlie adverse drug events and treatment outcomes.
    • A significant proportion of drug interactions are predictable based on known pharmacokinetic principles.

    Conclusions:

    • Drug interactions mediated by CYP enzymes and transporters are common and clinically significant.
    • Proactive management, including dose modification and selection of alternative agents, can mitigate risks.
    • Enhanced understanding of drug interaction mechanisms improves patient safety and therapeutic efficacy.