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Posterior subcapsular cataracts: posttransplantation in children
Insights
Posterior subcapsular cataracts (PSC) are common in renal transplant recipients. Higher prednisone dosage in the first year post-transplant correlates with PSC development and severity.
Area of Science:
- Ophthalmology
- Nephrology
- Transplantation
Background:
- Renal allograft recipients often experience ocular complications.
- Posterior subcapsular cataracts (PSC) are a significant concern in this population.
Observation:
- 60% of renal allograft recipients developed PSC.
- PSC onset occurred within the first post-transplant year in 30% and after the first year in 30%.
Findings:
- Prednisone dosage, adjusted for weight, during the first post-transplant year significantly correlated with PSC development.
- PSC severity was linked to the timing of onset and prednisone dosage.
Implications:
- Early detection and management of PSC are crucial in renal transplant patients.
- Optimizing immunosuppression protocols may mitigate cataract risk.
- Cataract extraction may be necessary to restore vision for daily activities, including education.
Abstract:
Posterior subcapsular cataracts (PSC) were noted in 41 of 69 (60%) recipients of renal allografts. The PSC were noted during the first posttransplant year (Group 1) in 21 (30%) recipients and after the first posttransplant (Group 2) year in 20 (30%) recipients. The dosage of prednisone during the first posttransplant year corrected for patient weight showed a significant correlation with the development of PSC during the first posttransplant year. The severity of the PSC were correlated with time of onset and prednisone dosage. Four recipients in Group 1 required cataract extraction to obtain sufficient vision to facilitate school work.