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Related Experiment Videos

[Testosterone substitution in the aging man].

H M Behre1, E Nieschlag

  • 1Universitätsklinik und Poliklinik für Urologie, Martin-Luther-Universität, Halle an der Saale.

Der Urologe. Ausg. A
|October 25, 2000
PubMed
Summary
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Interpersonal testosterone transfer after topical application of a newly developed testosterone gel preparation.

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Testosterone substitution of hypogonadal men prevents the age-dependent increases in body mass index, body fat and leptin seen in healthy ageing men: results of a cross-sectional study.

European journal of endocrinology·2002

Testosterone therapy is crucial for treating hypogonadism in aging men. Transdermal systems are currently preferred, with gels and injections showing future promise for hormone replacement.

Area of Science:

  • Endocrinology
  • Geriatrics
  • Pharmacology

Context:

  • Hypogonadism is a primary reason for testosterone replacement in aging males.
  • Selecting appropriate testosterone formulations is key for maintaining normal serum levels and allowing therapy cessation.
  • Current treatment options and emerging therapies are evaluated for efficacy and safety.

Purpose:

  • To review the indications and optimal choices for testosterone substitution therapy in aging men.
  • To discuss the benefits and drawbacks of various testosterone preparations.
  • To highlight future developments in testosterone therapy and necessary monitoring parameters.

Summary:

  • Transdermal testosterone systems are currently considered the most suitable option for testosterone substitution in aging men.

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  • Testosterone gels and intramuscular testosterone undecanoate represent promising future therapeutic developments.
  • Close monitoring of erythropoiesis and prostate health is essential during any testosterone therapy in aging males.

    • Impact:

    • Provides guidance for clinicians on selecting and managing testosterone therapy in the aging male population.
    • Informs patients about current and future treatment options for hypogonadism.
    • Contributes to the understanding of optimizing hormone replacement therapy for age-related conditions.