Injectable biodegradable polymer composites based on poly(propylene fumarate) crosslinked with poly(ethylene...

Area of Science:

• Biomaterials Science
• Polymer Chemistry
• Orthopedic Engineering

Background:

• Injectable, in situ crosslinkable biodegradable polymer composites are crucial for orthopedic tissue engineering.
• Developing materials with tailored mechanical properties and controlled degradation is essential for successful bone regeneration.

Purpose of the Study:

• To investigate novel injectable, in situ crosslinkable biodegradable polymer composites.
• To examine the effects of PEG-DMA/PPF double-bond ratio and beta-TCP content on composite properties.
• To engineer mechanical properties for orthopedic applications.

Main Methods:

• Formulation of polymer composites using PPF, PEG-DMA, and beta-TCP.
• Evaluation of crosslinking characteristics (maximum temperature, gel point).
• Assessment of mechanical properties (compressive strength, modulus) and water-holding capacity.

Main Results:

• Maximum crosslinking temperature remained constant at approximately 39.7°C.
• Gel points ranged from 8.0 to 12.6 minutes, unaffected by PEG-DMA content.
• Increasing PEG-DMA/PPF double-bond ratio enhanced compressive strength and modulus.
• Beta-TCP addition significantly improved mechanical properties.
• Water content increased with higher PEG-DMA/PPF ratios, but swollen mechanical properties decreased.

Conclusions:

• Injectable biodegradable polymer composites can be fabricated with tunable mechanical properties.
• The PEG-DMA/PPF ratio and beta-TCP content are key factors in controlling composite characteristics.
• These materials show promise for orthopedic tissue engineering applications.