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Related Experiment Video

Updated: Mar 27, 2026

Ceramic Omnidirectional Bioprinting in Cell-Laden Suspensions for the Generation of Bone Analogs

Ceramic Omnidirectional Bioprinting in Cell-Laden Suspensions for the Generation of Bone Analogs

Published on: August 8, 2022

Injectable dual-gelling cell-laden composite hydrogels for bone tissue engineering.

T N Vo¹, S R Shah¹, S Lu¹

¹Department of Bioengineering, Rice University, P.O. Box 1892, MS 142, Houston, TX, 77251-1892, USA.

|January 17, 2016

Summary

This summary is machine-generated.

Injectable hydrogels with gelatin microparticles and stem cells promote bone regeneration. These composite materials enhance bone ingrowth and integration in critical-sized defects, showing promise for bone tissue engineering applications.

Keywords:

Critical size cranial defect Gelatin microparticles Mesenchymal stem cells Mineralization N-isopropylacrylamide

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Published on: July 14, 2023

Area of Science:

Biomaterials Science
Regenerative Medicine
Tissue Engineering

Background:

Developing injectable hydrogels for bone regeneration is crucial.
Mesenchymal stem cells (MSCs) are key for bone repair.
Composite hydrogels offer tunable properties for cell delivery.

Purpose of the Study:

To investigate the osteogenic potential of injectable, dual-gelling composite hydrogels for MSC delivery.
To evaluate the in vitro and in vivo performance of these hydrogels for bone tissue engineering.

Main Methods:

Fabrication of N-isopropylacrylamide-based hydrogels with gelatin microparticles (GMPs).
In vitro assessment of MSC encapsulation, survival, and osteogenic markers.
In vivo evaluation in a rat critical-sized cranial defect model.

Main Results:

Hydrogels successfully encapsulated and maintained MSC viability in vitro.
GMP incorporation enhanced mineralization and alkaline phosphatase production.
In vivo, GMPs promoted bony bridging and mineralization; MSCs and GMPs facilitated tissue infiltration and osteoid formation.

Conclusions:

Injectable, dual-gelling composite hydrogels support MSC delivery and bone regeneration.
GMPs enhance osteogenesis and bone-implant integration.
These hydrogels show significant potential for bone tissue engineering applications.