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In vivo bioreactors for mandibular reconstruction.

A M Tatara1, M E Wong2, A G Mikos3

  • 1Department of Bioengineering, Rice University, Houston, Texas, USA.

Journal of Dental Research
|August 21, 2014
PubMed
Summary
This summary is machine-generated.

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In vivo bioreactors offer a promising solution for reconstructing large mandibular defects by creating patient-specific bone grafts. This approach aims to improve functional and aesthetic outcomes while minimizing donor site morbidity in craniofacial bone reconstruction.

Area of Science:

  • Regenerative Medicine
  • Biomaterials Engineering
  • Craniofacial Surgery

Background:

  • Reconstructing large mandibular defects presents challenges due to complex bone geometry.
  • Current free tissue flap transfer methods have limitations in shape fidelity and donor site morbidity.

Purpose of the Study:

  • To introduce the concept and application of in vivo bioreactors for craniofacial bone reconstruction.
  • To review preclinical models and summarize human cases utilizing in vivo bioreactor technology.
  • To discuss future directions for in vivo bioreactor-assisted mandibular reconstruction.

Main Methods:

  • Implantation of in vivo bioreactors in ectopic sites for tissue regeneration.
  • Utilizing bioreactors to guide ossified tissue growth in predefined geometries.
Keywords:
bioengineeringbone graft(s)bone remodeling/regenerationclinical studies/trialscraniomaxillofacial surgerytissue engineering

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  • Recruiting local vasculature for construct vascularization within the bioreactor.

    • Main Results:

    • In vivo bioreactors enable the generation of autologous prefabricated tissue flaps.
    • These flaps can be harvested with integrated vasculature for direct transfer.
    • Successful application in preclinical models and reported human cases demonstrates feasibility.

    Conclusions:

    • In vivo bioreactors represent a significant advancement in mandibular defect reconstruction.
    • This technology holds potential for improved functional and aesthetic outcomes.
    • Further research and clinical translation are warranted to optimize this regenerative approach.