Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Using progestins in clinical practice.

B S Apgar1, G Greenberg

  • 1University of Michigan Medical School, Ann Arbor, USA. bapgar@umich.edu

American Family Physician
|November 1, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pregnancy and perinatal outcomes of early vs late selective termination in dichorionic twin pregnancy: systematic review and meta-analysis.

Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology·2022
Same author

Preoperative MRI for oral tongue squamous cell carcinoma: timing and correlation to histopathology.

International journal of oral and maxillofacial surgery·2022
Same author

Temporomandibular joint involvement in patients with multiple myeloma-a retrospective study.

International journal of oral and maxillofacial surgery·2016
Same author

A new minimally invasive hybrid technique for femoro - above knee popliteal bypass.

International angiology : a journal of the International Union of Angiology·2012
Same author

Use of ViaBahn open revascularisation technique for above-knee femoro-popliteal anastomosis: a technical note.

European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery·2011
Same author

Atrophy of the lateral geniculate nucleus in human glaucoma detected by magnetic resonance imaging.

The British journal of ophthalmology·2008
Same journal

For Post-stent Patients With Atherosclerotic Coronary Vascular Disease Who Are Taking an Anticoagulant, Adding Aspirin Worsens Outcomes.

American family physician·2026
Same journal

Nausea and Vomiting During Pregnancy.

American family physician·2026
Same journal

Metabolic Dysfunction-Associated Steatotic Liver Disease: Diagnosis and Management.

American family physician·2026
Same journal

Aerobic Exercise Is the Better Exercise Modality for Knee Osteoarthritis.

American family physician·2026
Same journal

Overscreening Leads to Overdiagnosis of MASLD.

American family physician·2026
Same journal

Type 2 Diabetes: Outpatient Insulin Management.

American family physician·2026
See all related articles

Natural progesterone and its oral micronized form offer improved options for treating gynecological issues like irregular bleeding and preventing endometrial hyperplasia. These alternatives may have fewer side effects than synthetic progestins.

Area of Science:

  • Reproductive endocrinology
  • Pharmacology
  • Gynecology

Background:

  • Progestational agents are crucial for menstrual cycle regulation, treating uterine bleeding, and contraception.
  • Synthetic progestins have side effects, driving interest in natural progesterone alternatives.
  • Natural progesterone is available in various formulations, including oral micronized preparations with enhanced bioavailability.

Purpose of the Study:

  • To review the functions and formulations of progestational agents.
  • To compare natural progesterone with synthetic progestins, focusing on side effects and bioavailability.
  • To discuss the clinical applications of progestational agents in adolescents, perimenopausal women, and for contraception.

Main Methods:

  • Literature review of progestational agents, natural progesterone, and synthetic progestins.

Related Experiment Videos

  • Analysis of clinical applications in dysfunctional uterine bleeding, endometrial hyperplasia, and contraception.
  • Evaluation of formulation differences, bioavailability, and side effect profiles.

    • Main Results:

    • Oral micronized progesterone shows improved bioavailability and fewer side effects than synthetic progestins.
    • Progestational agents are vital for managing anovulatory bleeding and preventing endometrial hyperplasia.
    • Progestin-only contraceptives require strict adherence but offer options for estrogen-intolerant women; newer progestins aim to reduce androgenic effects.

    Conclusions:

    • Natural progesterone, particularly oral micronized forms, presents a favorable alternative to synthetic progestins due to improved tolerability and bioavailability.
    • Progestational agents remain essential in managing various gynecological conditions and for contraceptive purposes.
    • Further research is needed to clarify the risk of venous thromboembolic disease with newer progestins.