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A physical model of the human systemic arterial tree
G Ferrari1, A Nicoletti, C De Lazzari
1Institute of Biomedical Technologies, CNR, Roma, Italy. gfr@itbm.rm.cnr.it
The International Journal of Artificial Organs
|November 4, 2000
Summary
A physical model of the human arterial tree was created to improve mock circulatory systems for testing intra-aortic balloon pumps. This model accurately represents aortic impedance and waveforms, validating its use in cardiovascular research.
Area of Science:
- Biomedical Engineering
- Cardiovascular Physiology
Background:
- Accurate modeling of the human arterial tree is crucial for advanced cardiovascular research and device testing.
- Existing mock circulatory systems require enhanced capabilities for simulating complex arterial dynamics.
Purpose of the Study:
- To develop a physical model of the human arterial tree for a computer-controlled mock circulatory system (MCS).
- To accurately reproduce aortic impedance and associated flow/pressure waveforms for intra-aortic balloon pump (IABP) testing.
Main Methods:
- A multi-segment physical model of the aorta was designed using silicon rubber, with lumped parameter models for peripheral loads.
- Numerical simulations informed the physical model's dimensions and material properties (Young's modulus).
- Variable thickness was achieved using molds to replicate aortic segment characteristics.
Main Results:
- The physical model demonstrated stability and Young's modulus comparable to literature values.
- Measurements from numerical and physical models showed good agreement in pressure/flow waveforms and input impedance.
- Total static compliance of the aorta model was determined to be 1.5 cm³·mmHg⁻¹.
Conclusions:
- The developed physical arterial tree model effectively represents systemic arterial properties.
- The model enhances mock circulatory system capabilities for intra-aortic balloon pump testing.
- Results validate the model's accuracy against literature data for cardiovascular simulations.