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Indomethacin induced psychosis
D Tharumaratnam1, S Bashford, S A Khan
1Department of Elderly Care, Lister Hospital, Corey's Mill Lane, Stevenage, Herts SG1 4AB, UK.
Postgraduate Medical Journal
|November 4, 2000
Summary
Indomethacin, a common non-steroidal anti-inflammatory drug, can cause central nervous system side effects. An elderly patient developed psychosis while being treated with indomethacin for gout.
Area of Science:
- Pharmacology
- Neurology
- Geriatrics
Background:
- Indomethacin is a widely used non-steroidal anti-inflammatory drug (NSAID).
- Known adverse effects primarily involve the gastrointestinal and renal systems.
- Central nervous system (CNS) effects of indomethacin are less commonly recognized.
Observation:
- A case report details an elderly male patient.
- The patient was prescribed indomethacin for the treatment of gout.
- The patient presented with new-onset psychosis.
Findings:
- The case suggests a potential link between indomethacin use and the development of psychosis in elderly patients.
- This highlights a less-documented adverse effect of indomethacin.
Implications:
- Clinicians should consider CNS side effects, including psychosis, when elderly patients are treated with indomethacin.
- Further research may be warranted to elucidate the mechanisms of indomethacin-induced psychosis.
- This case contributes to understanding the full spectrum of indomethacin's adverse effects.