Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Morphology and immunophenotyping in hematological malignancies].

Y Kawai1, N Shimizu, M Ujiie

  • 1Department of Laboratory Medicine, Keio University, School of Medicine, Tokyo.

Rinsho Byori. the Japanese Journal of Clinical Pathology
|November 7, 2000
PubMed
Summary

Morphologic and immunophenotypic analysis are essential for accurate laboratory hematology diagnoses. Immunophenotyping significantly improves diagnostic rates, especially for non-Hodgkin lymphoma (NHL), aiding rapid and precise patient care.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

New MRI Findings in Fukuyama Congenital Muscular Dystrophy: Brain Stem and Venous System Anomalies.

AJNR. American journal of neuroradiology·2020
Same author

Different X-linked KDM5C mutations in affected male siblings: is maternal reversion error involved?

Clinical genetics·2016
Same author

An effective new method for the placement of an anti-adhesion barrier film using an introducer in laparoscopic surgery.

Techniques in coloproctology·2015
Same author

Deformation-driven p-wave halos at the drip line: 31Ne.

Physical review letters·2014
Same author

Operation status of the electron cyclotron resonance ion source at Gunma University.

The Review of scientific instruments·2014
Same author

Halo structure of the island of inversion nucleus 31Ne.

Physical review letters·2010

Area of Science:

  • Hematology
  • Immunology
  • Oncology

Context:

  • Evaluated 443 patients at Keio University Hospital (1994-1999).
  • Utilized morphology, cytochemistry, and laser flow cytometry for immunophenotyping.
  • Integrated cytogenetic and molecular genetic data for comprehensive diagnosis.

Purpose:

  • To assess the diagnostic utility of immunophenotyping compared to morphology in hematologic disorders.
  • To determine the diagnostic rate probability of immunophenotypic analysis using multivariate analysis.
  • To highlight the essential role of these methods in laboratory hematology.

Summary:

  • Diagnosed 150 acute leukemia (59 ALL, 91 AML), 74 MDS, 76 myeloproliferative disorders, 21 CLL-related disorders, 104 malignant lymphoma, and 18 multiple myeloma cases.

Related Experiment Videos

  • Immunophenotyping achieved an average diagnostic rate of 91.7%, with 97.1% for non-Hodgkin lymphoma (NHL).
  • Morphologic and immunophenotypic analyses are fundamental for rapid and precise hematologic diagnoses.

    • Impact:

    • Demonstrates the high diagnostic accuracy of immunophenotyping in hematologic malignancies.
    • Establishes immunophenotyping as a crucial tool for differentiating complex hematologic disorders.
    • Suggests tele-hematology could standardize morphologic methods for future diagnostics.