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Trends in mortality from leukemia in subsequent age groups.

F Levi1, F Lucchini, E Negri

  • 1Registre Vaudois des Tumeurs, Institut Universitaire de Médecine Sociale et Préventive, Centre Hospitalier Universitaire Vaudois, and Unité d'Epidémiologie du Cancer, Lausanne, Switzerland.

Leukemia
|November 9, 2000
PubMed
Summary

Leukemia mortality has significantly decreased in the European Union, particularly in younger age groups. However, declines in Eastern Europe were delayed and less pronounced, indicating disparities in therapeutic advancements.

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Area of Science:

  • Hematology
  • Epidemiology
  • Public Health

Background:

  • Leukemia mortality trends have varied globally.
  • Understanding these trends is crucial for assessing public health interventions.

Purpose of the Study:

  • To analyze age-standardized leukemia death certification rates from 1960-1997.
  • To compare trends in the European Union (EU) with other developed regions and Eastern Europe.

Main Methods:

  • Utilized World Health Organization database for death certification rates.
  • Analyzed trends across different age groups (0-14, 15-44, 45-59, 60-69, >=70).
  • Compared leukemia mortality in the EU, USA, Japan, and Eastern Europe.

Main Results:

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  • In the EU, leukemia mortality fell over 70% in children (0-14) and 40-45% in young adults (15-44).
  • Mortality declines were less significant in older age groups (45-59, 60-69).
  • Leukemia mortality in Eastern Europe showed later and smaller decreases compared to the EU.

    • Conclusions:

    • Significant reductions in leukemia mortality were observed in the EU, suggesting effective therapeutic advancements.
    • Comparable leukemia mortality rates in the EU, USA, and Japan by the late 1990s indicate similar impacts of advancements.
    • Disparities in Eastern Europe highlight the need for improved access to advanced leukemia treatments.