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Increased skin lactate in complex regional pain syndrome: evidence for tissue hypoxia?
F Birklein1, M Weber, B Neundörfer
1Neurologische Klinik, Friedrich-Alexander-Universität Erlangen, Germany. birklein@physiologie1.uni-erlangen.de
Neurology
|November 9, 2000
Abstract:
To investigate oxygen metabolism in complex regional pain syndrome (CRPS), the authors measured skin lactate via dermal microdialysis performed on patients with CRPS (n = 11) and healthy control subjects (n = 11). In addition, they measured blood lactate. Although venous lactate was unaltered, skin lactate was increased in patients with CRPS (2.95 mmol/L; control subjects 1.74 mmol/L; p < 0.005). These results suggest enhanced anaerobic glycolysis, probably as a result of chronic tissue hypoxia.