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Persistence of cryptococcomas on neuroimaging.

D R Hospenthal1, J E Bennett

  • 1Clinical Mycology Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. Duane.Hospenthal@amedd.army mil.

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
|November 14, 2000
PubMed
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Persistent brain lesions after cryptococcal meningitis treatment are common. These imaging findings do not indicate active infection, preventing misdiagnosis in patients cured with antifungal drugs.

Area of Science:

  • Neurology
  • Infectious Diseases
  • Radiology

Background:

  • Cryptococcal meningitis is a serious fungal infection affecting the central nervous system.
  • Neuroimaging is crucial for diagnosing and monitoring meningitis, but interpretation of findings can be challenging.

Observation:

  • Intracranial lesions were observed in three patients with cryptococcal meningitis.
  • These lesions persisted on computed tomography and magnetic resonance imaging for over five years.

Findings:

  • Successful antifungal treatment cured the patients' cryptococcal meningitis.
  • Despite cure, the intracranial lesions remained visible on neuroimaging studies.

Implications:

  • Persistent neuroimaging lesions should not be mistaken for active cryptococcosis.

Related Experiment Videos

  • This distinction is vital for accurate patient management and avoiding unnecessary treatments.