Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Update on inflammatory bowel disease genetics.

J Cho1

  • 1The Martin Boyer Laboratories, The University of Chicago, 5841 South Maryland Avenue, MC 6084, Chicago, IL 60637, USA. jcho@medicine.bsd.uchicago.edu

Current Gastroenterology Reports
|November 18, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Long-Range Transverse-Momentum Correlations and Radial Flow in Pb-Pb Collisions at the LHC.

Physical review letters·2026
Same author

Search for Quasiparticle Scattering in the Quark-Gluon Plasma with Jet Splittings in pp and Pb-Pb Collisions at sqrt[s_{NN}]=5.02  TeV.

Physical review letters·2025
Same author

First Measurement of A=4 Hypernuclei and Antihypernuclei at the LHC.

Physical review letters·2025
Same author

The prognostic and predictive value of pre-treatment hematologic markers for oropharyngeal carcinoma stratified by HPV status and treated with definitive (chemo) radiation.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology·2025
Same author

Probing Strangeness Hadronization with Event-by-Event Production of Multistrange Hadrons.

Physical review letters·2025
Same author

Psychiatric disorders in adolescent and young adult cancer survivors in Korea.

ESMO open·2025
Same journal

Management of Common Bile Duct Stones: Current Approaches and Evolving Endoscopic Strategies.

Current gastroenterology reports·2026
Same journal

Solitary Rectal Ulcer Syndrome Revisited: A Comprehensive Narrative Review.

Current gastroenterology reports·2026
Same journal

The Microbiome and Esophageal Disease: Where Are We Now?

Current gastroenterology reports·2026
Same journal

Fermented Durian Tempoyak as a Source of Probiotics for Colorectal Cancer Prevention through Gut Microbiome Modulation.

Current gastroenterology reports·2026
Same journal

A Practical Guide to Incorporating Novel Barrett's Screening/Surveillance Tools into Clinical Practice.

Current gastroenterology reports·2026
Same journal

The Role of Endoscopic Ultrasound in the Diagnosis and Management of Congenital Gastrointestinal and Pancreaticobiliary Conditions.

Current gastroenterology reports·2026
See all related articles

Genetic research is advancing the understanding of inflammatory bowel diseases (IBD), including Crohn's disease (CD) and ulcerative colitis (UC). Identifying genetic variants offers potential for personalized IBD treatments.

Area of Science:

  • Genetics
  • Gastroenterology
  • Immunology

Background:

  • Idiopathic inflammatory bowel diseases (IBD), encompassing Crohn's disease (CD) and ulcerative colitis (UC), are complex genetic disorders.
  • Recent advancements in human genomics facilitate systematic identification of genetic variants linked to IBD susceptibility.
  • Previous research indicated significant genetic linkages on multiple chromosomes, with chromosome 16 showing the strongest association for CD.

Purpose of the Study:

  • To systematically identify genetic variants contributing to IBD susceptibility.
  • To explore genetic linkages observed on various chromosomes for both CD and UC.
  • To investigate the role of candidate genes in inflammatory pathways relevant to IBD.

Main Methods:

  • Genome-wide linkage analysis to identify chromosomal regions associated with IBD.

Related Experiment Videos

  • Candidate gene association studies focusing on genes within inflammatory pathways (e.g., cytokines, cytokine receptors).

    • Main Results:

    • Established genetic linkage for CD on chromosome 16, with evidence for linkage on chromosomes 1, 6, 12, 14, and 19 for both CD and UC.
    • Association studies have largely concentrated on genes involved in inflammatory responses.

    Conclusions:

    • Understanding genetic underpinnings of IBD susceptibility and treatment response is crucial.
    • Genetic insights pave the way for personalized medical strategies in managing IBD patients.