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Working at the cutting edge: the creation of allosteric ribozymes
M Warashina1, T Kuwabara, K Taira
1National Institute for Advanced Interdisciplinary Research AIST, MITI 305-8562, Tsukuba Science City, Japan.
Structure (London, England : 1993)
|November 18, 2000
Abstract:
The appropriate folding of catalytic RNA is a prerequisite for effective catalysis. A novel ribozyme, the maxizyme, has been generated and its activity can be controlled allosterically. The maxizymes work both in vitro and in vivo indicating the potential utility of this novel class of ribozyme as a gene-inactivating agent with a biosensor function.