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[Waldenstrom disease revealed by a peripheral motor neuron disease]
N Vandenberghe1, S Pittion-Vouyouvitch, M Debouverie
1Bâtiment Neurologique, Hôpital Central, Nancy.
Background:
An association between motor neuron disease and Waldenström disease is rarely reported in the literature. The association with peripheral neuropathy and IgM monoclonal gammapathy is well known.
Case Report:
In our patient, the malignant monoclonal gammapathy had an unusual antigen pattern. This patient was MAG (myelin-associated glycoprotein) negative but showed a very positive serology for GM1 ganglioside and SGPG (3-sulfated glycuronly paragloboside).
Discussion:
This is the fifth such case to be reported associated a malignant dyglobulinemia with an MAG-negative IgM gammapathy. It is the first case with positive serology for both the GM1 ganglioside and SGPG.