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Related Experiment Videos

Lymphocytic and Collagenous Colitis.

Cruz-Correa1, Giardiello

  • 1Division of Gastroenterology, Department of Medicine, The Johns Hopkins University School of Medicine, 1830 East Monument Street, Room 431, Baltimore, MD 21205, USA.

Current Treatment Options in Gastroenterology
|November 30, 2000
PubMed
Summary

Patients with collagenous-lymphocytic colitis should modify their diet and medications. Treatments include anti-diarrheal agents, antibiotics, and anti-inflammatory drugs, with surgery reserved for refractory cases.

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Area of Science:

  • Gastroenterology
  • Internal Medicine
  • Colorectal Diseases

Background:

  • Collagenous-lymphocytic colitis is a condition causing chronic diarrhea.
  • Identifying effective treatment strategies is crucial for patient management.

Purpose of the Study:

  • To review current treatment options for symptomatic collagenous-lymphocytic colitis.
  • To provide guidance on dietary modifications, pharmacotherapy, and surgical interventions.

Main Methods:

  • Literature review of studies on collagenous-lymphocytic colitis treatment.
  • Analysis of therapeutic responses to various agents including dietary changes, medications, and surgery.

Main Results:

  • Dietary changes (e.g., eliminating secretagogues, low-fat diet) can help manage symptoms.

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  • Pharmacological options include anti-diarrheal agents, antibiotics (bismuth subsalicylate, metronidazole, erythromycin), sulfasalazine, 5-aminosalicylic acid compounds, and adrenocorticosteroids.
  • Sulfasalazine and 5-ASA compounds show significant efficacy, with adrenocorticosteroids used for treatment failures.
  • Surgical colectomy is an option for medically refractory cases.
  • Conclusions:

    • A stepwise approach to treatment, starting with conservative measures and progressing to more intensive therapies, is recommended.
    • Long-term management is often necessary, and alternative diagnoses should be considered if symptoms persist.