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Celiac Disease in the Elderly
Charlotte K Ching1, Benjamin Lebwohl2
1Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA.
Current Treatment Options in Gastroenterology
|February 23, 2023
Summary
Celiac disease is increasingly diagnosed in older adults, often presenting subtly. Early diagnosis and management are crucial due to potential complications and mortality risks.
Area of Science:
- Gastroenterology
- Geriatrics
- Immunology
Background:
- Celiac disease (CD) prevalence is rising in the elderly.
- CD in older adults is often underdiagnosed due to subtle, extraintestinal symptoms.
- Undiagnosed CD in the elderly carries risks of morbidity and mortality.
Purpose of the Study:
- To review recent literature on celiac disease in older adults.
- To explore current understanding of diagnosis, complications, and management.
- To identify knowledge gaps in the field.
Main Methods:
- Literature review of studies from recent years.
- Analysis of diagnostic criteria and challenges in the elderly.
- Examination of management strategies and outcomes.
Main Results:
- Older adults present with atypical symptoms, complicating diagnosis.
- Duodenal biopsy and serology are key diagnostic tools.
- Refractory celiac disease and lower mucosal healing rates are concerns in this population.
Conclusions:
- Understanding of celiac disease in the elderly is evolving.
- Significant knowledge gaps remain regarding pathogenesis, complications, and management.
- Further large-scale prospective studies are essential.
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