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Early-onset versus late-onset atypical depression: unipolar and bipolar II
1Department of Psychiatry, Public Hospital "Morgagni", National Health Service, 47100, Forlì, Italy. f.benazzi@fo.nettuno.it
Background:
To find differences between early- and late-onset atypical depression (AD).
Methods:
211 unipolar/bipolar II AD outpatients, interviewed with DSM-IV Structured Clinical Interview and depression rating scales. Logistic regression was used.
Results:
Early-onset AD was significantly associated with age, female gender, duration of illness, recurrences, chronicity, MADRS, bipolar II and unipolar. Early-onset bipolar II AD was significantly associated with age, female gender, duration of illness, recurrences and chronicity. Early-onset unipolar AD was significantly associated with age.
Limitations:
Age at onset recall bias, single interviewer, non-blind, cross-sectional assessment, bipolar II diagnosis reliability.
Conclusions:
Bipolar II AD is more likely to be chronic if early onset.