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Updated: Jul 17, 2026

Facile Preparation of 4-Substituted Quinazoline Derivatives
Published on: February 15, 2016
A new method for the synthesis of imidazolidinone- and benzimidazolone-containing
1Department of Chemistry, State University of New York, Buffalo, New York 14260-3000, USA.
Abstract:
A novel acid-catalyzed double nucleophilic addition of bisthiols to heterocyclic bisacetals gives sulfur-containing macrocycles in good yield. Crossover experiments revealed that the acid-catalyzed N-acyl iminium cyclization for the imidazolidinones is reversible. The sulfur atom in the bridge was extruded photochemically, giving new [2.2]heterophanes containing the imidazolidinone and benzimidazolone ring systems. The determined crystal structures for representative members in the benzimidazolone series are also reported.
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