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Updated: Aug 16, 2026

Mouse Kidney Transplantation: Models of Allograft Rejection
16:15

Mouse Kidney Transplantation: Models of Allograft Rejection

Published on: October 11, 2014

[Chronic renal allograft rejection. Part 2. Therapeutic possibilities]

O Viklický1, I Matl, J Lácha

  • 1Klinika nefrologie-Transplantacní centrum IKEM, Praha.

Casopis Lekaru Ceskych
|December 8, 2000
PubMed

Insights

Preventing chronic renal allograft rejection is crucial for long-term graft survival. This review explores novel immunosuppressants, risk factor management, and future gene therapies for preventing chronic rejection.

Area of Science:

  • Nephrology
  • Immunology
  • Transplantation

Context:

  • Chronic rejection is a leading cause of long-term renal allograft loss.
  • Understanding the etiopathogenesis of chronic rejection is key to developing new therapies.

Purpose:

  • To review current and future strategies for preventing chronic renal allograft rejection.
  • To provide a rational perspective on experimental evidence and therapeutic concepts.

Summary:

  • Novel immunosuppressants (mycophenolic acid, tacrolimus, rapamycin) and drugs targeting risk factors (lipid-lowering, ACE inhibitors, AT-1 blockers) may mitigate chronic rejection progression.
  • Future gene therapy holds promise for preventing chronic renal allograft rejection.

Impact:

  • Informs clinicians and researchers on current and emerging approaches to improve renal allograft survival.
  • Highlights the potential of multidisciplinary strategies in managing chronic rejection.

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