Autoanalytic (colormetric) determinations of SGOT in isoniazid recipients are reliable

A study was made to determine whether the ingestion of isoniazid interfered with the colormetric reaction used in most autoanalyzers to measure serum glutamic oxaloacetic transaminase (SGOT). Colormetric (autoanalytic) and noncolormetric (enzymatic) measurements of SGOT were made on a venous blood sample from each of 100 hospital employees who were taking isoniazid to prevent tuberculosis. The 2 techniques of measuring SGOT yielded comparable results. It was concluded that autoanalytic (colormetric) measurements of SGOT in isoniazid recipients are reliable.