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Structural basis of cell-cell interactions in the immune system

J Wang1, E L Reinherz

  • 1Dana-Farber Cancer Institute and Department of Pediatrics and Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA. jwang@red.dfci.harvard.edu

Current Opinion in Structural Biology
|December 15, 2000
PubMed

During the past year, advances in our understanding of receptor-ligand interactions between opposing cell surfaces have occurred at a structural level. These include adhesion involving CD2-CD58, antigen-specific T-cell receptor interactions with peptides bound to major histocompatibility complex molecules (both pMHCI and pMHCII), the CD8alphaalpha co-receptor-pMHCI interaction and the binding of two distinct classes of natural killer receptors to self-MHC ligands.

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