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Generation of Induced Regulatory T Cells from Primary Human Naïve and Memory T Cells
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The characterization and function of human immunoregulatory T lymphocyte subsets

E L Reinherz1, S F Schlossman

  • 1Division of Tumor Immunology, Sidney Farber Cancer Institute and the Department of Medicine, Harvard Medical School, Boston, MA 02115, U.S.A.

Immunology Today
|October 8, 2014
PubMed

Functional T lymphocyte subpopulations can be identified in humans by antibodies which detect stable glycoprotein antigens on their surface. Thus, inducer T lymphocytes bear an antigen termed T4 while suppressor T lymphocytes bear an antigen termed T5. Immune homeostasis results from a delicate balance between inducer and suppressor subsets within the T-cell circuit and perturbation in subset dynamics may initiate a wide variety of immunopathological disorders. Here Ellis Reinherz and Stuart Schlossman discuss the present understanding of this circuit, its role in the pathogenesis of a number of diseases and how the human immune response can be manipulated in an orderly way through modulation of selected T-cell subsets.

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