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Updated: Apr 22, 2026

Generating De Novo Antigen-specific Human T Cell Receptors by Retroviral Transduction of Centric Hemichain
Published on: October 25, 2016
The delineation of antigen receptors on human T lymphocytes
E L Reinherz1, S C Meuer, S F Schlossman
1The Division of Tumor Immunology, Sidney Farber Cancer Institute and the Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.
Abstract:
Monoclonal antibodies have identified several surface molecules involved in target cell recognition by cytotoxic human T cells. In this article it is proposed that T cells have two recognition units: a complex composed of the T3 molecule and a clonally unique glycoprotein which binds antigen associated with polymorphic MHC gene product; and the T4 or T8 molecule which binds to a constant region of an MHC gene product.
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