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[In Process Citation]

Schwarz-Eywill1, Rinaldi, Barth

  • 1I. Medizinische Klinik Stadtisches Klinikum|| Dresden-Friedrichstadt Friedrichstr. 41 D-01067 Dresden.

Zeitschrift Fur Rheumatologie
|December 16, 2000
PubMed
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Systemic lupus erythematosus can cause rare large-vessel vasculitis affecting iliac and femoral arteries. This manifestation impacts prognosis and treatment, highlighting the importance of early detection in lupus patients.

Area of Science:

  • Rheumatology
  • Vascular Medicine
  • Pathology

Background:

  • Systemic lupus erythematosus (SLE) is a chronic autoimmune disease.
  • Large-vessel vasculitis is a rare but serious complication of SLE.
  • Vascular involvement in SLE can significantly impact patient prognosis and management.

Purpose of the Study:

  • To report two cases of large-vessel vasculitis involving the external iliac and femoral arteries in patients with SLE.
  • To discuss the clinical significance, diagnostic challenges, and prognostic implications of this rare manifestation.
  • To correlate histological findings with the clinical presentation of vasculitis in SLE.

Main Methods:

  • Presentation of two distinct case reports of female patients diagnosed with SLE.

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  • Clinical evaluation including assessment of systemic symptoms and polyarthritis.
  • Vascular imaging (details not specified in abstract) to identify arterial occlusion.
  • Histopathological examination of affected arterial tissue in one case.

    • Main Results:

    • Both patients presented with occlusion of the right external iliac and femoral arteries.
    • The vasculitis occurred within the initial years of SLE diagnosis.
    • Histology in one case revealed fibrous thickening of the intima and vasculitis of small vessels in the adventitia.
    • General symptoms and polyarthritis were noted as other SLE manifestations.

    Conclusions:

    • Large-vessel vasculitis, specifically affecting iliac and femoral arteries, is a rare but significant manifestation of SLE.
    • Early recognition of this vascular complication is crucial for prognosis and guiding treatment strategies.
    • The findings support the concept that small vessel vasculitis is a characteristic feature of lupus erythematosus, even when large vessel involvement is present.