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Related Experiment Videos

Decrease in epidermal CD44 expression as a potential mechanism for abnormal hyaluronate accumulation in superficial

G Kaya1, E Augsburger, I Stamenkovic

  • 1Department of Dermatology, DHURDV, University Hospital of Geneva, Geneva, Switzerland. gkaya@hcuge.ch

The Journal of Investigative Dermatology
|December 20, 2000
PubMed
Summary

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Reduced CD44 in skin keratinocytes correlates with hyaluronate buildup in lichen sclerosus et atrophicus. This suggests CD44

Area of Science:

  • Dermatology
  • Molecular Biology
  • Extracellular Matrix Biology

Background:

  • CD44 is a key cell surface receptor for hyaluronate, a major extracellular matrix component.
  • CD44 functions as a cell adhesion molecule and is abundant in the skin.
  • Previous studies showed hyaluronate accumulation upon CD44 suppression in mouse keratinocytes.

Purpose of the Study:

  • To investigate the role of CD44 and hyaluronate in lichen sclerosus et atrophicus (LS&A).
  • To examine hyaluronate accumulation and CD44 expression in LS&A skin lesions.
  • To compare CD44 expression in LS&A with other skin conditions.

Main Methods:

  • Histological analysis of LS&A lesions using Alcian Blue and CD44 receptor globulin staining.
  • Immunohistochemistry and in situ hybridization to assess epidermal CD44 protein and mRNA expression.

Related Experiment Videos

  • Evaluation of CD44 expression in skin lesions of lupus erythematosus, scleroderma, and reticular erythematous mucinosis.

    • Main Results:

    • Hyaluronate accumulation was observed in the superficial dermis of LS&A lesions.
    • CD44 protein and mRNA expression were significantly decreased, sometimes lost, in the epidermis of LS&A lesions.
    • Keratinocyte CD44 expression remained unaltered in lupus erythematosus, scleroderma, and reticular erythematous mucinosis lesions.

    Conclusions:

    • Decreased keratinocyte CD44 expression is correlated with abnormal dermal hyaluronate accumulation in LS&A.
    • Reduced CD44 may play a pathogenetic role in the development of lichen sclerosus et atrophicus.
    • CD44's role in hyaluronate regulation is crucial in specific dermatological conditions.