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Related Experiment Videos

RefSeq and LocusLink: NCBI gene-centered resources.

K D Pruitt1, D R Maglott

  • 1National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Building 38A Room 6N605, 8600 Rockville Pike, Bethesda, MD 20894 USA. pruitt@ncbi.nlm.nih.gov

Nucleic Acids Research
|January 11, 2000
PubMed
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The National Center for Biotechnology Information (NCBI) offers LocusLink and RefSeq resources to manage vast gene data. These tools provide a unified view of genes and reference sequences for key genomes, aiding research.

Area of Science:

  • Genomics and Bioinformatics
  • Molecular Biology
  • Computational Biology

Background:

  • Thousands of genes have been identified, with many more predicted by large-scale sequencing projects.
  • The increasing volume of scientific literature necessitates organized gene and reference sequence information.
  • Existing data is fragmented, hindering comprehensive gene research.

Purpose of the Study:

  • To introduce and describe the LocusLink and RefSeq resources provided by the NCBI.
  • To highlight how these resources address the critical need for gene and reference sequence directories.
  • To explain the utility of LocusLink and RefSeq in supporting various areas of gene research.

Main Methods:

  • LocusLink consolidates gene-specific information, creating a central access point for model organisms.

Related Experiment Videos

  • RefSeq establishes reference sequence standards for genomes, transcripts, and proteins.
  • The study discusses human, mouse, and rat mRNA RefSeqs and their corresponding proteins.

    • Main Results:

    • LocusLink provides gene-centric access for fruit fly, human, mouse, rat, and zebrafish.
    • RefSeq offers standardized reference sequences for genomes, transcripts, and proteins.
    • Combined, LocusLink and RefSeq present a non-redundant view of genes and loci.

    Conclusions:

    • LocusLink and RefSeq are crucial NCBI resources for managing and accessing gene and reference sequence data.
    • These integrated resources support diverse research areas including gene families, variation, expression, and annotation.
    • The NCBI provides a comprehensive solution for the growing challenges in genomic data organization and utilization.