Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Switching attention--additional aspects for the analysis.

C van Thriel1, T Kleinsorge, M Zupanic

  • 1Institute for Occupational Physiology at the University of Dortmund, Germany. thriel@arb-phys.uni-dortmund.de

Neurotoxicology
|December 29, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Clinical outcomes of trifluridine/tipiracil plus bevacizumab versus trifluridine/tipiracil or regorafenib in metastatic colorectal cancer: a multicenter cohort study.

ESMO open·2026
Same author

Exploring the differences in the tumor microenvironment and immuno-oncologic targets in pancreatic ductal adenocarcinomas (PDAC) according to <i>KRAS</i> mutational status.

ESMO gastrointestinal oncology·2026
Same author

[PIMS-a new pediatric challenge].

Monatsschrift Kinderheilkunde : Organ der Deutschen Gesellschaft fur Kinderheilkunde·2021
Same author

Paraneoplastic Dermatomyositis: relevance of myositis-specific autoantibodies in a small cohort.

Journal of the European Academy of Dermatology and Venereology : JEADV·2019
Same author

Advances Using Single-Particle Trajectories to Reconstruct Chromatin Organization and Dynamics.

Trends in genetics : TIG·2019
Same author

[Nationwide survey of postgraduate medical training in clinical neurology].

Der Nervenarzt·2018
Same journal

Paternal Exposure to Chlorpyrifos Disrupts Protein Regulation and Abolishes PKCβ Signaling in Learning‑Related Neural Circuits.

Neurotoxicology·2026
Same journal

Zebrafish Behavioral Assessment as a First-Tier Whole-Organism NAM for Developmental Neurotoxicity: A Multi-Laboratory Evaluation.

Neurotoxicology·2026
Same journal

Adolescent prefrontal and amygdala molecular signatures of perinatal morphine versus buprenorphine exposure in mice.

Neurotoxicology·2026
Same journal

A Multiparametric 3D Cortical Neurosphere NAM for Developmental Neurotoxicity: Chlorpyrifos and a Biomonitoring-Anchored PFAS Mixture.

Neurotoxicology·2026
Same journal

Mechanisms of Nicotine Toxicity and Addiction-like Behavior in Drosophila melanogaster: The Role of α7 & β2 Nicotinic Acetylcholine Receptor Subunits in Sensory Valence and Cellular Stress.

Neurotoxicology·2026
Same journal

PM<sub>2.5</sub> exposure exacerbates cerebral infarction via HPG axis downregulation and pituitary lipid metabolism dysregulation in mice.

Neurotoxicology·2026
See all related articles

Long-term solvent exposure, particularly toluene, may affect attentional functions. While frontal cortex changes are suspected, neurobehavioral tests showed weak task-switching effects in exposed printing workers.

Area of Science:

  • Neurotoxicology
  • Neuroscience
  • Occupational Health

Background:

  • Attentional dysfunction is a known issue in long-term solvent exposure.
  • The frontal cortex is implicated in solvent-induced neurotoxicity.
  • Neurobehavioral tests, including task switching, can detect frontal lobe dysfunction.

Purpose of the Study:

  • To investigate attentional functions in rotogravure printing workers exposed to toluene.
  • To examine the impact of toluene exposure duration and level on cognitive performance.
  • To assess the utility of task switching paradigms in neurotoxicology.

Main Methods:

  • A longitudinal study with a cross-sectional design was conducted on 333 male rotogravure printing workers.
  • Participants underwent two examination periods, with 278 retested in the second period.

Related Experiment Videos

  • A neurobehavioral test battery, including the task switching attention (EURONES) test, was administered.

    • Main Results:

    • The expected interaction between task and response shifts was generally not observed.
    • No significant differences in task/response shifts were found between different exposure groups.
    • Weak task shift effects were detected in the subgroup of long-term exposed workers.

    Conclusions:

    • Standard interpretation of neurobehavioral tests may overlook task switching aspects.
    • Deviations in sequence condition frequencies might bias expectancies and mask underlying effects.
    • Future research should carefully balance conditions to improve the sensitivity of shift cost measurements in neurotoxicology studies.