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Noncovalent thrombin inhibitors incorporating an imidazolylethynyl P1
1Life Science R&D, LG Chemical Ltd/Research Park, Science Town, Taejon, South Korea. kleec@lgchem.co.kr
Bioorganic & Medicinal Chemistry Letters
|January 2, 2001
Abstract:
A series of noncovalent tripeptidic thrombin inhibitors incorporating a unidazolylethynyl moiety at P1 was investigated. A number of compounds of this series were highly potent and selective versus trypsin, and several compounds demonstrated good oral absorption in rats (F = 58% for compound 19).