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Effect of ascorbate and alpha-tocopherol on resistance of beta-carotene to oxidation
A I Kozachenko1, S M Gurevich, L G Nagler
1Laboratory of Physical and Chemical Basis of Cell Metabolsim Control, NM Emanuel' Institute of Biochemical Physics, Russian Academy of Sciences, Moscow. chembio@glasnet.ru
Bulletin of Experimental Biology and Medicine
|January 5, 2001
Abstract:
The efficiency of ascorbate and alpha-tocopherol as stabilizers of beta-carotene, which is widely used in complex therapy and prevention of some diseases accompanied by oxidative stress, was studied. The latency of induced beta-carotene oxidation linearly depends on ascorbate concentration, while steady-state rate nonlinearly depends on the concentration of alpha-tocopherol, which attests to involvement of antioxidants in various stages of chain oxidation of beta-carotene.