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Accumulation of exogenous histone in rat brain parenchyma
O A Gorukhina1, R D Ilyuk, I V Mishchenko
1Department of Biochemistry, AA Ukhtomsky Institute of Physiology, St Petersburg State University.
Bulletin of Experimental Biology and Medicine
|January 5, 2001
Abstract:
In vivo histoautoradiographic study of cerebral accumulation of exogenous histone after its intracarotid infusion to anesthetized rats with intact liver and animals with experimental cirrhosis showed that histone penetrates brain capillary endotheliocyte membranes and gets into the nervous tissue.