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The oxygen clock-a dual tracer physiological timer.

R J Nickles, Y F Au

    Physics in Medicine and Biology
    |January 1, 1975
    PubMed
    Summary
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    This study introduces a novel method using oxygen-19/oxygen-15 decay to measure regional oxygen age, crucial for understanding oxygen utilization in the body. However, the technique

    Area of Science:

    • Nuclear Medicine
    • Physiological Measurement
    • Radiochemistry

    Background:

    • Understanding oxygen dynamics is vital in physiology.
    • Current methods for measuring oxygen transit and utilization have limitations.
    • Radioisotopic tracers offer potential for in vivo physiological measurements.

    Purpose of the Study:

    • To develop and validate a method for measuring regional label 'age' using the in vivo differential decay of the radioisotopic pair oxygen-19 (19O) and oxygen-15 (15O).
    • To establish simplified expressions correlating measured age with oxygen transit times and utilization.
    • To assess the feasibility of simultaneous production and delivery of the 19O/15O label pair for physiological studies.

    Main Methods:

    • Simultaneous production of 19O/15O using a continuous flow, mixed-gas target irradiated by a tandem Van de Graaff accelerator.

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  • Flow-through chemistry and transport of the radioisotopes to a user site.
  • Recording gamma energy spectra using a twelve-probe detector array during normal breathing of doubly labeled air.
  • On-line computer analysis of recorded data.

    • Main Results:

    • Development of simplified expressions relating measured 'age' to oxygen transit times and utilization.
    • Successful simultaneous production and delivery of the 19O/15O radioisotopic pair.
    • Acquisition of gamma energy spectra during prolonged normal breathing experiments.

    Conclusions:

    • The 19O/15O differential decay method provides a novel approach to assess regional label 'age' in vivo.
    • The developed expressions offer a framework for interpreting oxygen transit and utilization.
    • The lack of compartment specificity with the 19O/15O pair presents challenges for precise interpretation of physiological processes.