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Complexometric determination of diphosphonic acid derivatives. Part II
M Podolska1, W Białecka, B Kwiatkowska-Puchniarz
1Drug Institute, 30/34 Chełmska Str., Warsaw, Poland.
Acta Poloniae Pharmaceutica
|January 6, 2001
Summary
This study introduces a new complexometric titration method for determining diphosphonic acid derivatives in osteoporosis medications. The method accurately quanties key compounds like alendronate in pharmaceutical preparations.
Area of Science:
- Analytical Chemistry
- Pharmaceutical Analysis
Background:
- Osteoporosis treatment relies on diphosphonic acid derivatives.
- Accurate quantification of these drugs in pharmaceuticals is crucial for patient safety and efficacy.
Purpose of the Study:
- To develop and validate a complexometric titration method for determining diphosphonic acid derivatives.
- To quantify specific drugs including disodium etidronate, disodium tiludronate, disodium pamidronate, and sodium alendronate.
Main Methods:
- Utilized a visual end-point complexometric titration.
- Employed thorium (IV) complexes with DCTA or EDTA as titrants.
- Employed xylenol orange or methyl thymol blue as indicators.
Main Results:
- Successfully developed a complexometric method for diphosphonic acid derivative determination.
- The method leverages the complex-forming abilities of these compounds for accurate titration.
Conclusions:
- The developed complexometric method provides a reliable means for analyzing diphosphonic acid derivatives in pharmaceutical formulations.
- This analytical approach supports quality control of osteoporosis medications.