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Microfabricated Platforms for Mechanically Dynamic Cell Culture
Published on: December 26, 2010
20-Hydroxyecdysone release from biodegradable devices: the effect of size and shape
M Dittrich1, P Solich, L Opletal
1Department of Pharmaceutics, Faculty of Pharmacy, Charles University, Heyrovského 1203, 500 05 Hradec Králové, Czech Republic.
Drug Development and Industrial Pharmacy
|January 9, 2001
Summary
This study developed biodegradable implants for continuous release of 20-hydroxyecdysone (20-OH) in agricultural animals. Hollow implants demonstrated prolonged drug delivery, ideal for in vivo testing.
Area of Science:
- Veterinary Pharmacology
- Biomaterials Science
- Drug Delivery Systems
Background:
- 20-Hydroxyecdysone (20-OH) is a natural compound known to enhance protein synthesis in vertebrates.
- A sustained-release formulation is needed for effective therapeutic applications in agricultural animals.
Purpose of the Study:
- To develop and evaluate biodegradable microparticles and implants for the continuous, long-term release of 20-OH.
- To assess the stability and release kinetics of 20-OH from poly(lactic acid)-based formulations.
Main Methods:
- Biodegradable microparticles and implants were fabricated using poly(L-lactic) and poly(DL-lactic) acids.
- A melt-based method was used to incorporate 20-OH into oligomers, forming microparticles by grinding and sieving.
- Implants were prepared as solid or hollow cylinders via extrusion and a novel air aspiration technique.
Main Results:
- 20-Hydroxyecdysone (20-OH) exhibited stability during the heat treatment processes.
- Both microparticle and implant formulations achieved prolonged in vitro drug release.
- Hollow cylinder implants demonstrated release kinetics closest to ideal zero-order, indicating suitability for in vivo studies.
Conclusions:
- Biodegradable poly(lactic acid) implants are a viable strategy for sustained delivery of 20-OH.
- Hollow implants offer promising controlled release profiles for future in vivo investigations in agricultural animals.
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