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Related Experiment Videos

Olfaction.

R L Doty1

  • 1Smell and Taste Center, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA. doty@mail.med.upenn.edu

Annual Review of Psychology
|January 10, 2001
PubMed
Summary
This summary is machine-generated.

Smell loss, an early indicator of neurodegenerative diseases like Alzheimer's and Parkinson's, is increasingly recognized. Advances in understanding olfactory mechanisms and measurement are driving new research and clinical applications.

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Area of Science:

  • Neuroscience
  • Olfactory research
  • Chemosensation

Background:

  • Olfactory systems research has surged due to genetic receptor insights, neurogenesis, and cell death.
  • Advances in psychophysical measurement have standardized olfactory testing.
  • Smell loss is an early sign of neurodegenerative diseases like Alzheimer's and Parkinson's.

Purpose of the Study:

  • To review recent progress in understanding olfactory function.
  • To emphasize olfactory transduction, measurement, and clinical findings.
  • To discuss the role of the vomeronasal system and pheromones.

Main Methods:

  • Review of recent scientific literature.
  • Focus on genetic, cellular, and psychophysical aspects of olfaction.

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  • Analysis of clinical findings related to smell loss.

    • Main Results:

    • Significant advances in understanding olfactory receptor mechanisms.
    • Evidence of neurogenesis and cell death in olfactory receptor cells.
    • Standardized olfactory tests reveal smell loss as an early disease biomarker.
    • Ongoing debate regarding human pheromone detection via the vomeronasal system.

    Conclusions:

    • Olfactory research is rapidly advancing, integrating molecular, cellular, and clinical perspectives.
    • Olfactory testing is crucial for early detection of neurodegenerative conditions.
    • Further research is needed to clarify the role of the vomeronasal system in humans.