Related Experiment Video

Updated: Aug 5, 2026

Dissecting Innate Immune Signaling in Viral Evasion of Cytokine Production
08:32

Dissecting Innate Immune Signaling in Viral Evasion of Cytokine Production

Published on: March 2, 2014

Mechanism of measles virus-induced suppression of inflammatory immune responses

J C Marie1, J Kehren, M C Trescol-Biémont

  • 1INSERM U503, CERVI, Immunobiologie Fondamentale et Clinique, 69365, Lyon, France.

Immunity
|February 13, 2001
PubMed

Insights

Measles virus (MV) proteins alone can suppress the immune system in mice, offering a new model to study measles and test vaccines. This research identifies specific viral proteins and cellular pathways involved in immune suppression.

Area of Science:

  • Virology
  • Immunology
  • Pathogen-host interactions

Background:

  • Measles virus (MV) causes severe immunosuppression, leading to high infant mortality, but the underlying mechanisms remain unclear.
  • A lack of suitable animal models has hindered research into MV-induced immune dysfunction.

Purpose of the Study:

  • To investigate the mechanisms by which measles virus proteins induce systemic immunosuppression.
  • To establish a novel animal model for studying MV-induced immune modulation and evaluating anti-measles vaccines.

Main Methods:

  • Utilized a mouse model to study the effects of specific MV proteins without viral replication.
  • Investigated two distinct pathways involving MV nucleoprotein/FcgammaR and MV glycoproteins/CD46.
  • Assessed immune responses including hypersensitivity, dendritic cell function, IL-12 production, and T cell proliferation.

Main Results:

  • Specific MV proteins, independent of replication, induced systemic immunosuppression in mice.
  • Identified two pathways: MV nucleoprotein-FcgammaR on dendritic cells and MV glycoproteins-CD46.
  • Observed impaired dendritic cell function, reduced IL-12 production, and diminished antigen-specific T cell proliferation.

Conclusions:

  • Introduced a novel mouse model for evaluating the immunosuppressive potential of anti-measles vaccines.
  • Revealed specific mechanisms of MV-induced immune modulation, highlighting the roles of nucleoprotein and glycoproteins.

More Related Videos

Phenotypic and Functional Analysis of Activated Regulatory T Cells Isolated from Chronic Lymphocytic Choriomeningitis Virus-infected Mice07:17

Phenotypic and Functional Analysis of Activated Regulatory T Cells Isolated from Chronic Lymphocytic Choriomeningitis Virus-infected Mice

Published on: June 22, 2016

Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo12:42

Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo

Published on: January 7, 2019

Related Concept Videos

T Cell Types and Functions01:24

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Cytotoxic T Cells-mediated Immune Response01:27

Cytotoxic T Cells-mediated Immune Response

Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
Immune Response Against Viral Pathogens01:29

Immune Response Against Viral Pathogens

The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
Vaccines01:21

Vaccines

Vaccines are among the most effective tools in preventive medicine, designed to prepare the immune system to recognize and combat infectious agents. By introducing antigens—substances that the immune system identifies as foreign—vaccines stimulate an adaptive immune response that leads to immunological memory. This immunological memory enables the body to mount a faster and more effective response upon future exposures to the actual pathogen.Vaccines can be categorized based on the type of...
Respiratory Syncytial Virus Disease01:29

Respiratory Syncytial Virus Disease

Human respiratory syncytial virus (RSV) is a widespread pathogen that primarily targets infants and young children but also poses a serious health risk to elderly and immunocompromised individuals. Belonging to the Pneumoviridae family, RSV is a negative-sense, single-stranded RNA virus within the Pneumovirus genus. Its global health burden is significant, with millions of cases annually resulting in hospitalizations and mortality, particularly in resource-limited settings. Although most...
Inhibitors Of Virion Release01:25

Inhibitors Of Virion Release

Viral replication and dissemination rely on efficient mechanisms for host cell entry, genome replication, assembly, and release. Influenza viruses, such as types A and B, are negative-sense single-stranded RNA viruses with a segmented genome, that depend on two critical surface glycoproteins to carry out these processes: hemagglutinin (HA) and neuraminidase (NA). HA initiates infection by binding to sialic acid residues on the surface of host epithelial cells, facilitating receptor-mediated...