Related Experiment Video
Updated: Oct 9, 2026

Murine Echocardiography of Left Atrium, Aorta, and Pulmonary Artery
Published on: February 20, 2017
Echocardiographic evaluation of cardiac functions and left ventricular mass in children with malnutrition
1Department of Pediatric Cardiology, Dr Sami Ulus Children's Hospital, Ankara, Turkey. burhan.ocal@isbank.net.tr
Insights
Children with protein energy malnutrition (PEM) show reduced left ventricular mass (LV Mass) and cardiac output, proportional to their smaller body size. However, their heart
Area of Science:
- Pediatric Cardiology
- Nutritional Science
- Echocardiography
Background:
- Protein energy malnutrition (PEM) affects multiple organ systems, including the cardiovascular system.
- Assessing cardiac structure and function in pediatric malnutrition is crucial for understanding its impact.
Purpose of the Study:
- To evaluate left ventricular mass (LV Mass) and systolic/diastolic functions in children with PEM.
- To compare cardiac parameters between children with PEM and healthy controls.
Main Methods:
- Doppler echocardiography was used to study 30 children with PEM (aged 2 months-2 years) and 17 healthy controls.
- Participants were categorized based on malnutrition type: kwashiorkor, marasmic-kwashiorkor, and marasmus.
Main Results:
- Children with PEM had significantly lower mean LV Mass compared to controls (P < 0.05).
- LV Mass, septal, and posterior wall thickness were reduced proportionally to body size in PEM, with the most significant reductions in the kwashiorkor group.
- Cardiac output was reduced in proportion to body size in PEM patients; however, cardiac index remained comparable to controls.
- Left ventricular systolic and diastolic functions were not significantly different between groups.
Conclusions:
- In children with PEM, LV Mass and cardiac output decrease proportionally with body size.
- Despite reduced cardiac dimensions, left ventricular systolic and diastolic functions are preserved in malnourished children.
Objective:
This study was undertaken to assess the left ventricular mass (LV Mass) and systolic and diastolic functions of the left ventricle in children with protein energy malnutrition (PEM).
Methodology:
Thirty children, aged between 2 months and 2 years with PEM (four kwashiorkor, seven marasmic- kwashiorkor, 19 marasmus), and 17 healthy, age-matched children, using Doppler echocardiography were studied.
Results:
The mean LV Mass in the patients was lower than that in the controls (14.5 +/- 5.2 vs 19.8 +/- 4.7 g, P < 0.05). However, the LV Mass/body surface area was not different in the patients with PEM and in the control group (52 +/- 9.2 vs 53.9 +/- 8.2g/m(2), P > 0.05), indicating that LV Mass was reduced in proportion to decrease in body size in malnutrition. Left ventricular septal and posterior wall thickness in PEM were also lower than that in the controls, and the most significant reduction in the LV Mass, septal and posterior wall thickness were found in the kwashiorkor group. Cardiac output was reduced in proportion to decrease in body size in the patient group (1.6 +/- 0.5 vs 2.1 +/- 0.8 L/min, P < 0.05), therefore cardiac index was not significantly different between the patients and the control subjects (5.9 +/- 1.4 vs 5.7 +/- 1.6 L/min/m(2), P > 0.05). Systolic function indices including ejection fraction, fractional shortening, and diastolic function indices were not significantly different in the groups.
Conclusions:
We demonstrated that LV Mass and cardiac output were reduced in proportion to decrease in body size in patients with PEM, and LV systolic and diastolic functions were preserved in atrophic hearts.
Related Concept Videos
Imaging Studies for Cardiovascular System I:Echocardiography
Indications: Echocardiography is utilized to diagnose heart failure, valve disorders, and myocardial infarction. It also assesses cardiac structures' size, shape, and motion, evaluates...
Mitral Stenosis II: Clinical features and Diagnostic Tests
Imaging Studies for Cardiovascular System II:Types of Echocardiography
Types of Echocardiography
Transthoracic Echocardiography (TTE)
TTE is the most common type of echocardiogram which involves placing a transducer on the patient's chest, emitting sound waves to create heart images. TTE is invaluable for evaluating the heart's size, structure, and motion, making it particularly useful for diagnosing...
Cardiomyopathy III: Hypertrophic Cardiomyopathy
Imaging Studies for Cardiovascular System III: X-Ray
Definition and Purpose
An X-ray, or radiograph, is a non-invasive method that uses ionizing radiation to take images of internal structures. It is mainly used in cardiac imaging to examine the heart, lungs, and major blood vessels, aiming to identify abnormalities in the heart's size, shape, and position, such as heart failure, congenital defects, and vascular...

