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Effects of skin occlusion on percutaneous absorption: an overview
1Department of Dermatology, University of California, School of Medicine, San Francisco, Calif 94143-0989, USA.
Skin Pharmacology and Applied Skin Physiology
|February 15, 2001
Abstract:
Skin occlusion produces profound changes, including hydration status, barrier permeability, epidermal lipids, DNA synthesis, microbial flora, and numerous molecular and cellular processes. It often, but not always, increases percutaneous absorption of applied chemicals. This overview focuses on the effect of skin occlusion on percutaneous absorption.