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Dapsone-induced photodermatitis in a patient with linear IgA dermatosis
1Department of Dermatology, University Hospital Carl Gustav Carus, Technical University of Dresden, Fetscherstr. 74, 01307 Dresden, Germany.
European Journal of Dermatology : EJD
|February 15, 2001
Summary
Dapsone (4, 4' diaminodiphenylsulfone) can cause photosensitivity, a rare side effect. This study shows it occurs in inflammatory skin disorders, not just leprosy, and involves dapsone metabolites.
Area of Science:
- Dermatology
- Pharmacology
Background:
- Dapsone (4, 4' diaminodiphenylsulfone) is an anti-inflammatory drug with known adverse effects like hemolytic anemia.
- Common dapsone metabolites include monoacetyldapsone (MADDS) and hydroxylamine dapsone (DDS-NOH).
Observation:
- A 76-year-old female patient with linear IgA dermatosis developed photosensitivity 8 weeks after starting dapsone therapy.
- The patient presented with a widespread erythematous eruption on UV-exposed skin.
- Photopatch testing confirmed positive reactions to dapsone, MADDS, and DDS-NOH.
Findings:
- Dapsone-induced photosensitivity is reported for the first time in a patient with linear IgA dermatosis.
- This adverse reaction is not limited to leprosy patients.
- Dapsone metabolites (MADDS and DDS-NOH) may contribute to photosensitivity, similar to the parent drug.
Implications:
- Dapsone-induced photosensitivity is a rare, non-dose-related adverse effect.
- This reaction can occur in patients with various inflammatory skin disorders, not exclusively leprosy.
- Clinicians should consider dapsone-induced photosensitivity in patients with inflammatory skin conditions presenting with UV-sensitive eruptions.