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Related Concept Videos

Skin Diseases and Disorders01:23

Skin Diseases and Disorders

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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
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Disorders of Leukocytes01:27

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Leukocyte disorders can lead to either leukopenia, characterized by an abnormally low leukocyte count, or leukocytosis, marked by a very high leukocyte number.
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Changes in Skin Color: Clinical Perspectives01:14

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The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
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Regulation of Hematopoietic Stem Cells01:01

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All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
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Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

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Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
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Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling
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[Skin disorders in malignant hematologic diseases].

M Schmid-Wendtner1, T Hornung, M Meurer

  • 1Interdisziplinäres Onkologisches Zentrum (IOZ) München, Nußbaumstr. 12, 80336, München, Deutschland, m.schmid-wendtner@ioz-muenchen.de.

Der Hautarzt; Zeitschrift Fur Dermatologie, Venerologie, Und Verwandte Gebiete
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PubMed
Summary
This summary is machine-generated.

Skin manifestations in hematologic malignancies are common. This review details vascular, unspecific, specific, and paraneoplastic skin disorders, focusing on clinical findings and treatments for paraneoplastic syndromes.

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Area of Science:

  • Dermatology
  • Hematology
  • Oncology

Context:

  • Hematologic malignancies frequently present with diverse cutaneous manifestations.
  • Skin lesions can be indicative of underlying hematologic disorders, impacting diagnosis and prognosis.
  • Understanding these dermatologic signs is crucial for comprehensive patient care.

Purpose:

  • To review and categorize the spectrum of skin lesions associated with hematologic malignancies.
  • To highlight clinical findings and therapeutic strategies for paraneoplastic skin disorders.
  • To provide a comprehensive overview for clinicians managing patients with blood cancers.

Summary:

  • Skin lesions are classified into three main groups: vascular changes, unspecific/specific lesions (e.g., leukemia cutis), and paraneoplastic disorders.
  • The review emphasizes clinical presentations and treatment options for the most common paraneoplastic syndromes in hematologic malignancies.
  • It covers skin disorders arising from vascular alterations, opportunistic infections, and immune-related phenomena.

Impact:

  • Improved recognition and diagnosis of hematologic malignancies through dermatologic examination.
  • Enhanced patient management by addressing both the malignancy and its cutaneous sequelae.
  • Facilitates a multidisciplinary approach to care, integrating hematology and dermatology expertise.