Detection of protein with anticonsolidation properties in the rat brain
1A. I. Karaev Institute of Physiology, Azerbaijanian Academy of Sciences, Baku. Arifm@iphysiol.azeri.com
Bulletin of Experimental Biology and Medicine
|February 15, 2001
Abstract:
Isolation and identification of rat brain protein regulated by serotonin-modulated protein SMP-69 is described. Intracerebral administration of anti-SMP-69 antibodies activates cerebral cortex cell genome and increases the content of electropheretic fraction 28. Intracerebral administration of isolated and purified protein to rats disturbed memory consolidation. It is concluded that nerve cells have a molecular switch regulating consolidation of memory traces.
