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Effects of apolipoproteins C on oxidative phosphorylation in rat liver mitochondria
L E Panin1, N I Shalbueva, L M Polyakov
1Institute of Biochemistry, Siberian Division of Russian Academy of Medical Sciences, Novosibirsk.
Bulletin of Experimental Biology and Medicine
|February 15, 2001
Abstract:
It is shown that apoC-III, but not other apoC proteins, components of very low density lipoproteins (apoC-I, apoC-II, apoC-III), reduced the rate of mitochondrial respiration in various metabolic states. This effect depended on the dose of apoprotein, type of oxidized substrate, and the presence of Ca ions in the incubation medium. ApoC-III completely blocked oxidative phosphorylation during oxidation of palmitoyl carnitine by mitochondria, while the respiration rate in metabolic state 4 remained unchanged.