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Antiamnesic effect of acyl-prolyl-containing dipeptide (GVS-111) in compression-induced damage to frontal cortex
G A Romanova1, T K Mirzoev, I V Barskov
1Institute of General Pathology and Pathophysiology; Institute of Pharmacology; Brain Research Institute, Russian Academy of Medical Sciences, Moscow.parochial@mtu-net.ru
Bulletin of Experimental Biology and Medicine
|February 15, 2001
Abstract:
Antiamnestic effect of acyl-prolyl-containing dipeptide GVS-111 was demonstrated in rats with bilateral compression-induced damage to the frontal cortex. Both intraperitoneal and oral administration of the dipeptide improved retrieval of passive avoidance responses in rats with compression-induced cerebral ischemia compared to untreated controls.