Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Maximum Likelihood classification rule for assessing acute toxicity]

Sabine Glaser1, Hartmut Hecker

  • 1Institut für Biometrie, Medizinische Hochschule D-Hannover.

ALTEX
|January 1, 1996
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Portosystemic Hepatic Encephalopathy Scores (PHES) differ between Danish and German healthy populations despite their geographical and cultural similarities.

Metabolic brain disease·2024
Same author

Capmatinib plus nazartinib in patients with EGFR-mutated non-small cell lung cancer.

European journal of cancer (Oxford, England : 1990)·2024
Same author

Determination of Turkish norms of psychometric tests for diagnosing minimal hepatic encephalopathy and proposal of a high sensitive screening test battery.

Hepatology international·2021
Same author

Temperatures in the pulpal cavity during orthodontic bonding using an LED light curing unit : An in vitro pilot study.

Journal of orofacial orthopedics = Fortschritte der Kieferorthopadie : Organ/official journal Deutsche Gesellschaft fur Kieferorthopadie·2020
Same author

Antiviral treatment perspective against Borna disease virus 1 infection in major depression: a double-blind placebo-controlled randomized clinical trial.

BMC pharmacology & toxicology·2020
Same author

Increased frequency of CD4<sup>+</sup> CD25<sup>high</sup> CD127<sup>low</sup> T cells early after lung transplant is associated with improved graft survival - a retrospective study.

Transplant international : official journal of the European Society for Organ Transplantation·2020
Same journal

New approach methodologies as first tier in an integrated approach to testing and assessment for non-genotoxic carcinogens.

ALTEX·2026
Same journal

Assessing the FDA's Year One Progress Report on Reducing Animal Testing.

ALTEX·2026
Same journal

Europe's roadmap finally arrives: Long on rigor, short on a clock.

ALTEX·2026
Same journal

Towards advanced in vitro models of testicular steroidogenesis for endocrine disruption testing.

ALTEX·2026
Same journal

Evaluation of EndoSens: A reliable skin sensitization assessment model.

ALTEX·2026
Same journal

Serum-free in vitro assessment of receptor-mediated endocrine activity including Phase-1 metabolism.

ALTEX·2026
See all related articles

A new method for classifying substance toxicity offers an alternative to the Acute Toxic Class (ATC) method. This approach uses fewer animals and provides reliable, even superior, toxicity classification for substances with high LD50 values.

Area of Science:

  • Toxicology
  • Chemical Safety
  • Pharmacology

Background:

  • The Acute Toxic Class (ATC) method is a standard for classifying chemical toxicity.
  • There is a need for efficient and reliable methods in toxicological classification.
  • Accurate toxicity classification is crucial for risk assessment and regulatory compliance.

Purpose of the Study:

  • To propose a simple, alternative procedure for classifying substances into toxicity classes.
  • To evaluate the proposed method's performance against the established ATC method.
  • To determine the efficiency in terms of animal usage and classification reliability.

Main Methods:

  • Development of a novel classification procedure based on the maximum likelihood principle.
  • Comparative analysis with the Acute Toxic Class (ATC) method.

Related Experiment Videos

  • Assessment of the number of experimental animals required.
  • Evaluation of classification reliability and accuracy.

    • Main Results:

    • The proposed method requires a similar number of experimental animals compared to the ATC method.
    • The reliability of the proposed classification is comparable to the ATC method.
    • The new procedure demonstrates considerably better performance for substances with true LD50 values of 2000 mg/kg body weight and above.

    Conclusions:

    • The proposed maximum likelihood-based method is a viable and efficient alternative to the ATC method.
    • This method offers comparable or superior reliability in toxicity classification, especially for less toxic substances.
    • The procedure contributes to more accurate and potentially more ethical toxicological assessments.