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New Heck-type reaction applied to the synthesis of protoporphyrin-IX derivatives
M Castella1, F Calahorra, D Sainz
1Departament de Química Orgànica and Departament de Química Inorgànica, Universitat de Barcelona, Martí i Franqués 1-11, E-08028 Barcelona, Catalunya, Spain.
Organic Letters
|February 17, 2001
Abstract:
[reaction: se text] A new Heck-type reaction under catalysis by Pd for obtaining polysubstituted arylvinylydene derivatives of porphyrin systems is reported. The coupling between the Zn(II)-protoporphyrin-IX dimethylester Zn-2 and several bromo-aryl and iodo-aryl compounds in the presence of a new Pd catalyst has been studied. This coupling reaction, although providing moderate regioselectivity, gives quantitative conversion.