Activity of detoxication enzymes in rat hepatoma 27 transplanted in different organs

Activities of enzymes of active oxygen forms detoxication and phase II xenobiotic metabolism were measured in rat hepatoma 27 cells transplanted to different organs. Activity of phase II xenobiotic metabolizing enzymes was higher in hepatoma cells growing subcutaneously than in those transplanted into the liver, while activity of active oxygen forms detoxication enzymes (except catalase) was higher in cells transplanted into the liver. Benz(a)pyrene induced the enzyme activities in hepatoma growing both subcutaneously and in the liver.