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Seroconversion rate following measles vaccination

S Gunawardena1, V Bandaranayake

  • 1Department of Immunology, Medical Research Institute, Colombo.

The Ceylon Medical Journal
|February 24, 2001
PubMed

Insights

Measles vaccination in Sri Lankan infants shows a high seroconversion rate of 93.06%. This indicates the vaccine is effective in preventing measles in young children.

Area of Science:

  • Pediatric Infectious Diseases
  • Immunology
  • Public Health

Background:

  • Measles remains a significant public health concern globally, particularly in regions with lower vaccination coverage.
  • Infant susceptibility to measles necessitates timely and effective vaccination strategies.
  • Understanding seroconversion rates is crucial for evaluating vaccine efficacy.

Purpose of the Study:

  • To determine the seroconversion rate of measles vaccination in infants in Sri Lanka.
  • To assess the immunogenicity of the measles vaccine in a Sri Lankan pediatric population.

Main Methods:

  • A descriptive study was conducted at the Lady Ridgeway Hospital, Colombo.
  • 134 infants attending the immunization clinic were enrolled.
  • Serum samples were collected pre- and post-vaccination and tested for anti-measles IgG antibodies using ELISA.

Main Results:

  • Out of 102 infants with post-vaccination samples, 101 were initially seronegative.
  • 94 out of 101 seronegative infants developed antibodies post-vaccination, yielding a seroconversion rate of 93.06%.
  • This rate is comparable to findings from international studies.

Conclusions:

  • The measles vaccine demonstrates high efficacy in inducing an immune response in Sri Lankan infants.
  • Current vaccination practices at 9 months of age are supported by these findings.
  • Further research is recommended to ascertain the long-term protection duration conferred by a single measles vaccine dose.
Abstract

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