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Related Experiment Videos

Controlled release of vancomycin from biodegradable microcapsules.

Y Ozalp1, N Ozdemir, S Kocagöz

  • 1Faculty of Pharmacy, Department of Pharmaceutical Technology, Ankara University, Turkey.

Journal of Microencapsulation
|February 24, 2001
PubMed
Summary
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This study developed Poly D,L-lactic acid (PLA) and PLGA microcapsules for vancomycin delivery. Optimized formulations showed high encapsulation efficiency and sustained 4-day bactericidal effects against S. aureus.

Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Pharmaceutical Sciences

Background:

  • Methicillin-resistant Staphylococcus aureus (MRSA) infections necessitate effective drug delivery systems.
  • Vancomycin hydrochloride is a critical antibiotic for treating MRSA.
  • Biodegradable polymers like PLA and PLGA offer potential for controlled drug release.

Purpose of the Study:

  • To synthesize and characterize Poly D,L-lactic acid (PLA) and its copolymers (PLGA) for vancomycin microencapsulation.
  • To investigate the impact of preparation parameters on microcapsule properties and drug release.
  • To evaluate the in vitro efficacy of vancomycin-loaded microcapsules.

Main Methods:

  • Polymerization of PLA and PLGA (90:10, 70:30) with molecular weights of 12,000-40,000 Da.

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  • Water-oil-water (w/o/w) double emulsion and solvent evaporation for vancomycin microencapsulation.
  • Analysis of encapsulation efficiency, microcapsule size, in vitro release kinetics, and degradation via SEM and Tg measurements.

    • Main Results:

    • Increased polymer-to-drug ratio and emulsifier molecular weight enhanced encapsulation efficiency.
    • In vitro vancomycin release was influenced by polymer molecular weight, copolymer type, and 60Co sterilization.
    • Microcapsule degradation was observed, correlating with increased release rates and decreased glass transition temperatures (Tg).

    Conclusions:

    • Optimized PLA and PLGA microcapsules effectively encapsulate vancomycin hydrochloride.
    • The microencapsulation process parameters significantly influence product characteristics and drug release profiles.
    • Sterilized vancomycin-loaded microcapsules demonstrated sustained in vitro bactericidal activity against S. aureus for up to 4 days.